loperamide ivive-pbpk model simcyp animal simulator (Simcyp)
90
Structured Review
Simcyp
loperamide ivive-pbpk model simcyp animal simulator
Loperamide Ivive Pbpk Model Simcyp Animal Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/simcyp+ivive+simulations/loperamide+ivive+pbpk+model+simcyp+animal+simulator/pm40457124-3-2-5
Average 90 stars, based on 1 article reviews
Loperamide Ivive Pbpk Model Simcyp Animal Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/simcyp+ivive+simulations/loperamide+ivive+pbpk+model+simcyp+animal+simulator/pm40457124-3-2-5
Average 90 stars, based on 1 article reviews
loperamide ivive-pbpk model simcyp animal simulator - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator. Article Snippet: We identify here for the first time the low-affinity cytochrome P450 (P450) isoforms that metabolize paroxetine, using cDNA-expressed human P450s measuring substrate depletion and paroxetine-catechol (product) formation by liquid chromatography-tandem mass spectrometry.. CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion.. Michaelis-Menten constants Km and Vmax were determined by product formation and substrate depletion. |